Application | Comment | Organism |
---|---|---|
medicine | studies on ability of staphopain B of Staphylococcus aureus to elicit and maintain a chronic inflammatory state, staphopain B suggested to mediate recruitment of specialized host cells, including immunoregulatory plasmacytoid dendritic cells and/or macrophages | Staphylococcus aureus |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Staphylococcus aureus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | isolated from culture medium | Staphylococcus aureus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Staphylococcus aureus | staphopain B shown as a potent trigger of chemerin, the tazarotene-induced gene 2 protein TIG2, normally acting as a ligand for the G-protein coupled receptor CMKLR1, activation shown by proteolytic cleavage of the C-terminus | ? | - |
? | |
additional information | Staphylococcus aureus NCTC 8325 | staphopain B shown as a potent trigger of chemerin, the tazarotene-induced gene 2 protein TIG2, normally acting as a ligand for the G-protein coupled receptor CMKLR1, activation shown by proteolytic cleavage of the C-terminus | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | Q2FZL3 | strain 8325-4 including isogenic knockout mutants in the 8325-4 genetic background | - |
Staphylococcus aureus NCTC 8325 | Q2FZL3 | strain 8325-4 including isogenic knockout mutants in the 8325-4 genetic background | - |
Purification (Comment) | Organism |
---|---|
recombinant and native protein, gel filtration | Staphylococcus aureus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
culture medium | - |
Staphylococcus aureus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
proteolytic cleavage of the C-terminus of chemerin, the tazarotene-induced gene 2 protein TIG2, by staphopain B determined by SDS-PAGE, HPLC-analysis and MALDI-TOF, cell-activating potential of chemerin cleavage products determined, clinical isolates of Staphylococcus aureus shown to activate chemerin, activation determined in the presence of plasma inhibitors, no activation of chemerin by staphopain B mutants observed | Staphylococcus aureus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | staphopain B shown as a potent trigger of chemerin, the tazarotene-induced gene 2 protein TIG2, normally acting as a ligand for the G-protein coupled receptor CMKLR1, activation shown by proteolytic cleavage of the C-terminus | Staphylococcus aureus | ? | - |
? | |
additional information | staphopain B shown as a potent trigger of chemerin, the tazarotene-induced gene 2 protein TIG2, normally acting as a ligand for the G-protein coupled receptor CMKLR1, activation shown by proteolytic cleavage of the C-terminus | Staphylococcus aureus NCTC 8325 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SspB protein | - |
Staphylococcus aureus |
staphopain B | - |
Staphylococcus aureus |